Longevity and NAD+ formulas: what is permitted in Europe
NAD+ is the star molecule of the longevity market. But between NMN, NR and vitamin B3, not every ingredient is permitted in Europe. Here is how to build a formula that sells and stays compliant.
- NAD+ is a coenzyme present in all our cells and essential for energy production. Its level declines with age.
- Vitamin B3 (niacin, nicotinamide) is a permitted NAD+ precursor with official claims: niacin contributes to the reduction of tiredness and fatigue and to normal energy-yielding metabolism.
- Nicotinamide riboside (NR) is authorised as a novel food in supplements, under specific conditions.
- NMN is not yet authorised in Europe: EFSA issued a favourable opinion in 2026, but Commission authorisation is still pending.
- Irati Production designs and manufactures compliant longevity formulas as capsules, powders or gummies.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell. It is involved in converting nutrients into energy and in many cellular mechanisms. Research shows that its level falls with age, hence the “longevity” market’s interest in molecules that can support its production.
NAD+ itself is rarely used as such in supplements. Formulators instead use its precursors: molecules the body converts into NAD+.
NAD+ precursors: what is permitted
Vitamin B3 is therefore the building block of a compliant NAD+ formula: it allows authorised claims, for example that niacin contributes to the reduction of tiredness and fatigue and to normal energy-yielding metabolism (NRV: 16 mg per day).
NMN: where do things stand?
NMN (nicotinamide mononucleotide) is considered a novel food in Europe. In May 2026, EFSA issued a favourable safety opinion on a specific NMN at 300 mg per day for the general adult population, excluding pregnant and breastfeeding women. Formal authorisation now depends on the European Commission and the Member States. Until it is published, NMN cannot be sold as a food supplement in the EU.
For a brand, this is an opportunity: prepare a formula now, so you are ready on the day of authorisation, with a manufacturer who follows the file closely.
Other ingredients in a longevity formula
- Spermidine from wheat germ extract: authorised as a novel food, under specific conditions.
- Resveratrol (trans-resveratrol): authorised as a novel food with a maximum dose.
- Coenzyme Q10: a classic ingredient in energy formulas.
- Vitamins and minerals: vitamin C, vitamin E, zinc and selenium contribute to the protection of cells from oxidative stress (authorised claims).
- Polyphenols and plant extracts: handle claims with care.
Example of a compliant “NAD+ Energy” formula
Pitfalls to avoid
- Promising to “slow down ageing” or “rejuvenate cells”: these are prohibited claims.
- Selling NMN before it is authorised: a non-compliant product, with a risk of withdrawal and penalties.
- Exceeding the doses set by novel food authorisations (NR, resveratrol, spermidine).
- Forgetting the mandatory labelling statements specific to novel foods.
Your longevity range, compliant and ready to sell
The longevity market is booming. We help you enter it with a formula that is scientifically and regulatorily sound.
- NAD+ formulas based on vitamin B3 and NR, antioxidants, CoQ10
- Regulatory monitoring on NMN so you are ready as soon as it is authorised
- Capsules, powders, sticks, gummies
- Drafting of claims and labelling
- Made in France, ISO 22000-certified site
Frequently asked questions
Is NMN authorised in the EU?
Not yet. EFSA issued a favourable opinion in 2026, but the European Commission’s authorisation has not yet been published. In the meantime, NMN cannot be sold as a food supplement.
What is the difference between NMN and NR?
Both are NAD+ precursors. Nicotinamide riboside (NR) is already authorised as a novel food in Europe; NMN is going through the authorisation process.
Which supplement boosts NAD+?
In Europe, vitamin B3 (niacin or nicotinamide) is the simplest NAD+ precursor to use, with authorised claims. NR is also permitted under certain conditions.
Can you write “anti-ageing” on a supplement?
No. Claims about slowing down ageing are not authorised. Communicate on validated claims instead, such as the reduction of tiredness and fatigue or the protection of cells from oxidative stress.
Does Irati Production manufacture longevity formulas?
Yes. We develop and manufacture compliant longevity formulas as capsules, powders and gummies. Contact us.
This article is for information only and does not constitute medical or legal advice. Regulatory status as at 1 October 2026, subject to change. Sources: Regulation (EU) No 432/2012; Regulation (EU) 2015/2283 (novel foods) and the Union list; EFSA opinion on NMN (2026).